caffeine metabolism genetic variations

The Genetics of Caffeine Metabolism: Why Coffee Affects People Differently

You metabolize caffeine primarily through the CYP1A2 enzyme, encoded by the CYP1A2 gene, which varies genetically between individuals. These genetic differences classify you as a slow or fast metabolizer, affecting how long caffeine’s effects last and your sensitivity to its stimulation. Additionally, genes like ADORA2A influence your response to caffeine’s impacts on the nervous system….

coffee s impact on digestion

Coffee and Digestion: How Coffee Affects Your Gut

When you drink coffee, it stimulates your stomach’s parietal cells to produce more acid, aiding digestion but potentially worsening reflux or gastritis. Coffee also speeds up gut motility, triggering muscle contractions that promote bowel movements through the gastrocolic reflex. Its bioactive compounds influence gut microbiota, supporting beneficial bacteria growth. Decaffeinated coffee still affects acid secretion,…