The Genetics of Caffeine Metabolism: Why Coffee Affects People Differently
You metabolize caffeine primarily through the CYP1A2 enzyme, encoded by the CYP1A2 gene, which varies genetically between individuals. These genetic differences classify you as a slow or fast metabolizer, affecting how long caffeine’s effects last and your sensitivity to its stimulation. Additionally, genes like ADORA2A influence your response to caffeine’s impacts on the nervous system….